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| Intravital Molecular Imaging Satoshi Nishimura Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo Dr. Satoshi Nishimura is a world-renowned expert of intravital molecular imaging; which means in vivo imaging of microcirculation and molecular dynamics in living animals with high spatiotemporal resolution. Intravital Molecular imaging is a powerful tool to elucidate not only vascular pathological conditions such as arteriosclerosis, but also to study molecular mechanisms of pathological conditions caused by complicated and multi-cellular abnormal interactions, such as cancer or metabolic syndrome. He has developed imaging system based on highly spatiotemporal imaging with the CSU and visualized microcirculation, vascular functions and multi-cellular dynamics of target molecules in real-time and in threedimensions, in vivo. Using this technique, he successfully elucidated how obese adipose tissue played a bad role in obesity. |
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An example of real-time movie of microcirculation in mouse, which clearly shows dynamic movement and interactions among leucocytes, platelets, macrophages and endothelium. Play (size:10,706 KB) |
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Cellular kinetics in microcirculation Play (size:2,097 KB) |
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Deformed erythrocyte and platelets in microcirculation Play (size:4,750 KB) |
