High Content Analysis

Yokogawa’s high-content analysis systems, also known as high-content screening systems, address a range of research applications from basic science to drug discovery screening. Paired with our advanced analysis software, our HCA systems provide high quality 3D imaging for enhanced live cell analysis.

  • CellVoyager CV8000 is the most advanced high-content screening system. The improved built-in incubator lets you analyze extended live cell responses. With its expandability, four cameras, five lasers and an optional built-in pipettor, the system permits increasingly complex assay development and high-content screening.

  • The CQ1 provides the highest quality confocal images and extended live cell imaging in a space-saving benchtop design. 

  • With powerful machine learning functions, our analysis software suite provides researchers with advanced insights into their HCA experiments such as label-free analysis.

We post our information to the following SNSs.
Please follow us.

 

Yokogawa Life Science

•Twitter @Yokogawa_LS
•Facebook Yokogawa Life Science
•LinkedIn Yokogawa Life Science

 

Yokogawa's Official Social Media Account List

Social Media Account List

Confocal imagers with powerful analysis software

Our high content analysis systems are the best solutions for a range of research applications from basic science to drug discovery screening.

High Content Analysis

HCA is an automated research method that uses image analysis to closely examine target cells in chronological order based on single or multiple parameters. Its wide potential for investigating complex life events and phenotypes makes HCA a most promising tool for next generation drug discovery and pharmaceutical research.

Yokogawa's HCA system combines key benefits from conventional research analysis methods while addressing certain drawbacks. 

 

Traditional Methods High Content Analysis
High-Throughput Screening (HTS) Flow Cytometry Microscopy

Strength:

  • High-speed handling of a large number of samples

Weakness:

  • Calculates only averages for wells

Strength:

  • Acquires numeric data on individual cells

Weakness:

  • Adherent cells must be removed

Strength:

  • Detailed observation of cellular events

Weakness:

  • Slow

Strengths:

  • Rapidly analyzers a large number of samples
  • Detailed observation of cellular events
  • Temporal analysis of live cells
  • Acquires numeric data on invidividual cells
  • Automated high-speed imaging and analysis
  • Adherent cells can be observed as is
Application Note
Application Note
Overview:

Cell clusters are directly measured with high-throughput 3D imaging
Confocal Quantitative Image Cytometer

Application Note
Overview:

List of Selected Publications : CQ1

Application Note
Overview:

List of Selected Publications : CV8000, CV7000, CV6000

Application Note
Overview:

The CQ1 confocal image acquisition mechanism with the distinctive CSU® unit has a function to sequentially acquire fine cell images along the Z-axis and capture information from the entire thickness of
cells which include heterogenic populations of various cell cycle stages. In addition, saved digital images can be useful for precise observation and analysis of spatial distribution of intracellular molecules.
The CQ1 capability to seamlessly analyze images and obtain data for things such as cell population statistics to individual cell morphology will provide benefits for both basic research and drug discovery
targetingM-cell cycle phase.

Overview:

In this tutorial, we will learn how to perform cell tracking with CellPathfinder through the analysis of test images.

Overview:

In this tutorial, using images of zebrafish whose blood vessels are labeled with EGFP, tiling of the images and recognition of blood vessels within an arbitrary region will be explained.

Overview:

In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.

Overview:

In this tutorial, we will learn how to perform time-lapse analysis of objects with little movement using CellPathfinder, through calcium imaging of iPS cell-derived cardiomyocytes.

Overview:

In this tutorial, we will observe the change in number and length of neurites due to nerve growth factor (NGF) stimulation in PC12 cells.

Overview:

In this tutorial, image analysis of collapsing stress fibers will be performed, and concentration-dependence curves will be drawn for quantitative evaluation.

Overview:

In this tutorial, we will identify the cell cycles G1-phase, G2/M-phase, etc. using the intranuclear DNA content.

Overview:

In this tutorial, intranuclear and intracytoplasmic NFκB will be measured and their ratios calculated, and a dose-response curve will be created.

Overview:

In this tutorial, spheroid diameter and cell (nuclei) count within the spheroid will be analyzed.

Overview:

In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.

Yokogawa Technical Report
1.2 MB
Yokogawa Technical Report
The World as Seen from Cells
(rd-te-r06002-001)
2.2 MB
Yokogawa Technical Report
6.1 MB

Product Overviews

    Product Overview
    Overview:

    The CV8000 features a cell incubator with an improved airtight design that facilitates the observation of cell behavior over long periods of time. In addition, the CV8000 comes with CellPathfinder, a new program that can analyze images of unlabeled cells and 3D images of samples. With these features, the CV8000 improves the efficiency of drug discovery research and biomedical research on leading-edge subjects such as iPS and ES cells.

Looking for more information on our people, technology and solutions?


Contact Us
Top