CQ1 enables 3D imaging and quantification of live cell clusters, such as spheroids within a 3D culture vessel, as they are, keeping the cells intact. CQ1 exports feature data in general formats which are readable by various third-party software for advanced data analysis. It is possible to construct fully customized CQ1-based system by integrating with external systems*1, via robot for culture dish handling.
|Excitation laser wavelength||405 nm, 488 nm, 561 nm, 640 nm|
|Objective lens||2x to 60x
(Dry, Phase contrast, Long working distance)
|Camera||High-sensitivity sCMOS camera|
|Autofocus||Laser autofocus, Software autofocus|
|CQ1||General fluorescent imaging||Flow cytometry|
|Cell removal/suspension treatment||Not necessary||Not necessary||Necessary|
|Cell image confirmation||Possible||Possible||Not possible|
|Display feature data and graphs in real-time with imaging||Possible||Depends on devices||Possible|
|3D data measurement||Possible||Not possible||Not possible|
|Time lapse||Possible||Not possible||Not possible|
*2 Contact to CQ1 partner for more information
Compact design contains fully integrated multiple functions to offer easy-to-handle confocal imaging system, without a need for complicated system integration; you only need to set a sample and run the software. User-friendly interface and versatile functions support your measurement and analysis.
A Nipkow spinning disk containing about 20,000 pinholes and a subsidiary spinning disk containing the same number of microlenses to focus excitation laser light into each corresponding pinhole are mechanically fixed on a motor, and very rapidly rotated. As a result, high-speed raster scan of the excitation lights on the specimen can be achieved.The pinhole and microlenses are arranged on each disk in our proprietary design to optimize raster scan. Multi-beam scanning not only increases scanning speed, but also results in significantly lower photobleaching and phototoxicity, because multi-beam excitation needs only low level of laser power on the specimen to fully excite fluorescence.
Software learns the features of the sampleobjects collected by users.
DPC*2 function is a powerful tool to analyze unstained bright field samples.
*1 Optional software
*2 Digital phase contrast
|Optics||Microlens enhanced dual wide Nipkow disk confocal,
Phase contrast (Optional add-on)
|Laser/Filter||Laser : Choose 2-4 lasers from 405/488/561/640nm,
10-position Filter wheel (built-in)
|Camera||sCMOS 2560×2160pixel, 16.6×14.0mm|
|Objective lens||Max.6 lenses
(Dry: 2x, 4x, 10x, 20x, 40x Long working distance: 20x, 40x
Phase contrast: 10x, 20x )
|Sample vessel||Microplate (6, 24, 96, 384 well), Slide glass,
Cover glass chamber*1, Dish (35, 60mm*1)
|XY stage||High-precision XY stage, designated resolution 0.1µm|
|Z focus||Electric Z motor, designated resolution 0.1µm|
|Autofocus||Laser autofocus, Software autofocus|
|Feature data||Number of cells/cellular granules, Intensity, Volume, Surface area, Area, Perimeter, Diameter, Sphericity, Circularity, etc|
|Data format||Image : 16bit TIFF file (OME-TIFF), PNG
Numerical data : FCS, CSV, ICE
|Workstation||Measurement and analysis workstation|
|Size/weight||Main unit : 600×400×298mm 38kg
Utility box : 275×432×298mm 18kg
|Environment||15 - 30oC、20 - 70％RH No condensation|
|Power consumption||Main unit and Utility box : 100-240VAC 800VAmax, Workstation : 100-240VAC 650VAmax|
*1 Under development *2 Display is not included with CQ1 system
Russia, Ukraine, Kazakhstan, Belarus, Azerbaijan, Armenia, Georgia, Uzbekistan, Turkmenistan, Kyrgyzstan, Tajikistan, and Moldova
Shanghai Genesci Medical technology Co.,Ltd.
People's Republic of China (excluding Hong Kong, Taiwan, Macao)
De Novo Software has been developing flow cytometer data analysis solutions since 1998. Our flagship product, FCS Express™, is world-renowned as a robust, and easy to use flow and image cytometry data analysis application. De Novo Software offers a dedicated image analysis and reporting package for Image Cytometry to improve your workflow and results while giving you access to single cell results evening with high content screening data. FCS Express Image cytometry is directly compatible with the Yokogawa CQ1 quantitative image cytometer through the .ICE file format which enables quick import, analysis, and reporting of your results in FCS Express.
CellPathfinder is designed for our HCA systems, CQ1 and the CellVoyager series. From beginners to experts, the analysis software lets you quantify subtle physiological changes and even label-free samples with various graph options.
CellActivision uses Machine Learning Technology and a unique digital filter to recognise cells or colonies directly from label free images. CellActivision can also classify and quantify these cells by the use of sample libraries which are easily prepared by the user.
The CQ1 confocal image acquisition mechanism with the distinctive CSU® unit has a function to sequentially acquire fine cell images along the Z-axis and capture information from the entire thickness of
cells which include heterogenic populations of various cell cycle stages. In addition, saved digital images can be useful for precise observation and analysis of spatial distribution of intracellular molecules.
The CQ1 capability to seamlessly analyze images and obtain data for things such as cell population statistics to individual cell morphology will provide benefits for both basic research and drug discovery
targetingM-cell cycle phase.
List of Selected Publications : CQ1
Instrumentation devices and equipment serve for plants as the eyes, ears, nose, tongue, and skin, which are responsible for the five senses, and act as the central nervous system and brain do for human beings. The reliability and availability of such devices and equipment are the most important requirements of customers.
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