Merck Serono Biotech CenterHighly Advanced Biopharmaceutical Plant Uses CENTUM VP, VP Batch, Exaquantum and PRMExecutive summaryThe Merck Serono Biotech Center (MSBC) in Corsier-sur-Vevey, Switzerland, is the center of Biotech Manufacturing & Process Development of Merck Serono. It produces biopharmaceuticals, which are composed of large molecular structures such as proteins that are created from live cells using recombinant DNA technology. Operational since 1999, the MSBC is one of the largest and most technologically advanced biotech centers in the world, producing biotech products for clinical trials and commercial phases, and is also engaged in the development of high-performance processes. This site has particular expertise from small to large scale mammalian cell culture technologies, and uses many different technology platforms. The site currently produces the active ingredient for Merck Serono’s multiple sclerosis treatment, Rebif ® (interferon beta-1a) and for the targeted cancer therapy Erbitux ® (cetuximab). An expansion project to increase capacity at the site was recently completed in order to allow for world-scale production of monoclonal antibodies as Erbitux ® and other biopharmaceuticals. The new facility is comprised of an upstream plant (USP), a downstream plant (DSP), a utility area for supplying clean media as water, air and steam for the production and moreover an on-site waste water treatment plant. For this new large-scale biotech (LSB) production facility, Yokogawa Deutschland GmbH of Ratingen, Germany installed the CENTUM VP production control system, VP Batch package, Exaquantum/Batch plant information management system, and PRM plant resource management package along with more than 2,000 FOUNDATION™ Fieldbus devices and nearly 6,500 PROFIBUS™ control valves. To assist in this undertaking, Yokogawa Deutschland enlisted the support of its Swiss branch office (established in 1999) and also entered into strategic partnerships with local engineering and service partners. Merck Serono later concluded a lifecycle maintenance agreement with this Swiss office.Plant InformationLocation: Vevey, SwitzerlandOrder date: 2007Completion: September 2012Operator guided by electronic batch record (EBR) at USP43Success Story CollectionChemical (Fine & Specialty Chemical, Biofuel)& Pharmaceutical

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