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Janssen PharmaceuticaAccurate Measuring of SolventsExecutive summaryThe Geel plant of Janssen Pharmaceutica is a chemical synthesis plant which makes primary API’s. This is done through use of an extensive number of solvents. In order to load the batch reac-tors with the right quantity of solvent, there was a need for highly precise mass flow meters. Even though this customer had no experience with RotaMASS, we succeeded in selling 18 pieces.Janssen Pharmaceutica is part of Johnson & Johnson, the largest company in the world in the field of healthcare. The company has three facilities in Belgium. The facility in Geel is known for the production of active substances (called API or Active Phar-maceutical Ingredients) for the medicines that are manufactured in the facility in Beerse. The facility in Olen only provides quality research. The facility in Geel has four production plants in which various reactions can be carried out: for this reason they are called multipurpose plants. The process generally consists of the following components:•Various raw materials, originating from tanks or storage are brought together with the necessary solvents and auxiliary substances.•Large reactors of between 1000 and 6000 liters form the heart of the production process. Here chemical reactions take place between the different raw materials and a new substance is formed.•By means of centrifuges or filters, the solvents that are required for the reaction are separated out of the remaining product. The majority of these solvents are recycled and stored in tanks.•Finally, the product is dried to remove the last traces of solvent: resulting in a dry powder.For the final products, the story hasn't finished yet. In order to be able to measure these powders correctly and add them to medicines in small quantities they have to have the right consistency and grain size. To that end, the facility in Geel has a separate department, the powder unit, where the active substances are ground and sifted.A Yokogawa RotaMASS is used to precisely measure the recuperated solvents that are pumped from the tanks to the various reactors. RotaMASS is a mass flow meter based on the Coriolis effect.Plant InformationLocation: Geel, BelgiumOrder date: March 2006Completion: September 2006Four production plants45Success Story CollectionChemical (Fine & Specialty Chemical, Biofuel)& Pharmaceutical

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