{"id":1445,"date":"2024-01-05T09:20:05","date_gmt":"2024-01-05T08:20:05","guid":{"rendered":"https:\/\/www.yokogawa.com\/eu\/blog\/life-innovation\/?p=1445"},"modified":"2024-02-20T13:32:30","modified_gmt":"2024-02-20T12:32:30","slug":"innovative-research-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.yokogawa.com\/eu\/blog\/life-innovation\/innovative-research-in-alzheimers-disease\/","title":{"rendered":"Innovative Research in Alzheimer&#8217;s Disease Powered by Yokogawa&#8217;s Single Cellome\u2122 System SS2000"},"content":{"rendered":"\n<div class=\"wp-block-uagb-image uagb-block-59daef9c wp-block-uagb-image--layout-default wp-block-uagb-image--effect-static wp-block-uagb-image--align-none\"><figure class=\"wp-block-uagb-image__figure\"><img decoding=\"async\" srcset=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/SS2000_front-1024x502.png \" sizes=\"(max-width: 480px) 150px\" src=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/SS2000_front-1024x502.png\" alt=\"Single Cellome SS2000\" class=\"uag-image-1447\" width=\"1024\" height=\"502\" title=\"\" loading=\"lazy\"\/><figcaption class=\"uagb-image-caption\">Yokogawa&#8217;s Single Cellome System SS2000<\/figcaption><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-winner-of-our-single-cellome-system-ss2000-research-equipment-grant-program\">The Winner of our <strong>Single Cellome\u2122 System SS2000<\/strong> Research Equipment Grant Program<\/h2>\n\n\n\n<p>Yokogawa proudly presents the winner of our first <strong>Single Cellome\u2122 System <\/strong>SS2000 Research Equipment Grant Program: The first place grant goes to the Department of Psychiatry and Psychotherapy, <a href=\"https:\/\/www.unimedizin-mainz.de\/psychiatrie\/homepage\/homepage.html?L=1\">University Medical Center Johannes Gutenberg-University<\/a> in Mainz.<\/p>\n\n\n\n<p><strong>Prof. Dr. rer. nat. Kristina Endres<\/strong> at the University Medical Center in Mainz and <strong>Prof. Dr. phil. nat. Kristina Friedland <\/strong>at<strong> <\/strong>the Institute of Pharmacy and Biomedical Sciences, Johannes Gutenberg-University in Mainz, are glad to receive the research equipment grant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-using-the-ss2000-for-alzheimer-research\">Using the SS2000 for Alzheimer Research<\/h2>\n\n\n\n<p><strong>Prof. Endres <\/strong>and <strong>Prof Friedland<\/strong> utilize SS2000 to study Alzheimer\u2019s disease, which is the main cause of dementia.<\/p>\n\n\n\n<div class=\"wp-block-uagb-image uagb-block-6c6612ea wp-block-uagb-image--layout-default wp-block-uagb-image--effect-static wp-block-uagb-image--align-none\"><figure class=\"wp-block-uagb-image__figure\"><img decoding=\"async\" srcset=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/93513511_m-1024x404.jpg \" sizes=\"(max-width: 480px) 150px\" src=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/93513511_m-1024x404.jpg\" alt=\"\" class=\"uag-image-1449\" width=\"3263\" height=\"1286\" title=\"\" loading=\"lazy\"\/><figcaption class=\"uagb-image-caption\">Picture Credits: vectorfusionart\/ 123RF<\/figcaption><\/figure><\/div>\n\n\n\n<p><strong>Why is it crucial to find a cure for Alzheimer&#8217;s disease?<\/strong><\/p>\n\n\n\n<ol type=\"1\" start=\"1\">\n<li><strong>Growing Prevalence<\/strong>: Alzheimer&#8217;s disease is one of the most common forms of dementia, affecting millions of people worldwide. Its prevalence is increasing as the global population ages, making the search for a cure increasingly urgent.<\/li>\n\n\n\n<li><strong>Impact on Quality of Life<\/strong>: Alzheimer&#8217;s disease significantly impacts the quality of life of both patients and their caregivers. It leads to a progressive decline in cognitive functions, affecting memory, reasoning, and the ability to perform daily tasks. Finding a cure would greatly improve the lives of those affected.<\/li>\n\n\n\n<li><strong>Economic Burden<\/strong>: The care for Alzheimer&#8217;s patients is costly in terms of direct healthcare expenses and indirect costs such as lost productivity and caregiver time. A cure could alleviate the substantial economic burden on families and healthcare systems.<\/li>\n\n\n\n<li><strong>Advancement in Neuroscience<\/strong>: Finding a cure for Alzheimer&#8217;s disease would represent a major advancement in neuroscience and our understanding of the brain. This could potentially lead to breakthroughs in treating other neurological disorders.<\/li>\n\n\n\n<li><strong>Prevention of Disease Progression<\/strong>: Currently, available treatments only manage symptoms without halting the progression of the disease or have rather limited efficacy. A cure would offer a way to stop or reverse the progression, fundamentally changing the trajectory of the disease.<\/li>\n<\/ol>\n\n\n\n<p><strong>To find a cure, you need to understand the nature of the disease<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-research-of-prof-endres\">Research of Prof. Endres<\/h2>\n\n\n\n<blockquote class=\"wp-block-quote\">\n<p>\u201e I first became interested in Alzheimer&#8217;s research as an undergraduate student when my former boss and mentor, Professor Fahrenholz, offered me a project on Abeta-related proteins. I was deeply moved to learn that so many people and their families suffer from this disease and have no access to a cure. So I got involved and am still trying to change this situation.\u201d<\/p>\n<cite>Prof. Kristina Endres<\/cite><\/blockquote>\n\n\n\n<p>Prof. Endres is the head of the working group \u201cMolecular mechanisms of healthy aging and neurodegeneration.\u201d Her research is focused on Alzheimer\u2019s disease regarding pathogenesis, therapy, and prevention. With her background as a technician in a pharmaceutic company and her studies in biology and biochemistry, she has a broad spectrum of techniques and expertise from both fields, industry and academia. Moving to the Medical Center of the University allowed Prof. Endres to widen her expertise into translational approaches with clinical studies as the endpoint. <\/p>\n\n\n\n<p>In her PostDoc phase, she acquired a funding from the German ministry (BMBF) that supported her research on retinoids as therapeutics in Alzheimer\u2019s disease. Later on, multiple University internal and third-party fundings supported the widening of her area of interest e.g., the interplay between microbiome and Alzheimer\u2019s disease. During the projects, she successfully established collaborations with bioinformaticians, microbiologists, immunologists, and chemists, as well as medical doctors, which allowed her to publish about 90 papers until today. Her research on retinoid-based therapy was also recognized with the Hans-J\u00f6rg Weitbrecht Price for clinical neuroscience in 2015.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-the-use-of-the-ss2000-will-contribute-to-the-research\">How the use of the SS2000 will contribute to the research <\/h2>\n\n\n\n<p>Investigating time and spatial dimensions of mitochondrial failure in microglia upon approaching amyloid plaques using the <a href=\"https:\/\/www.yokogawa.com\/eu\/solutions\/products-and-services\/life-science\/single-cellome\/ss2000\/\">Single Cellome\u2122 System SS2000<\/a> will help uncover mechanistic insights into Alzheimer\u2019s disease.<\/p>\n\n\n\n<p>Microglia are a type of immune cell in the brain that are believed to play a significant role in Alzheimer&#8217;s disease. They are linked to key features of the disease. One example of this link is how a harmful peptide, called Abeta, interacts with these cells. Abeta accumulates in the brains of Alzheimer&#8217;s disease patients, forming what are known as senile plaques. The researchers plan to grow microglia cells in a lab setting alongside these Abeta plaques, a process known as co-culturing. They will then collect samples from different parts of the microglia cells. These samples will be rich in mitochondria, which are important parts of the cell. They&#8217;ll gather these samples from areas close to the plaques, areas further away, and from cells that haven&#8217;t been near the plaques at all. This will help them understand how the disease affects these cells at a very detailed level.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-ss2000-research-equipment-grant-program\">The SS2000 Research Equipment Grant Program<\/h2>\n\n\n\n<p>Endres and Friedland received a Single Cellome\u2122 SS2000 for up to 4 months, plus live training and ongoing technical support from our experts, Dr. Fredrik Wieland and Dr. David Sustr.<\/p>\n\n\n\n<div class=\"wp-block-uagb-image uagb-block-e38d14eb wp-block-uagb-image--layout-default wp-block-uagb-image--effect-static wp-block-uagb-image--align-none\"><figure class=\"wp-block-uagb-image__figure\"><img decoding=\"async\" srcset=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/friedland-and-endres-ss2000-grant-1024x663.jpg \" sizes=\"(max-width: 480px) 150px\" src=\"https:\/\/www.yokogawa.com\/eu\/blog\/app\/uploads\/sites\/9\/2024\/01\/friedland-and-endres-ss2000-grant-1024x663.jpg\" alt=\"\" class=\"uag-image-1453\" width=\"1384\" height=\"896\" title=\"\" loading=\"lazy\"\/><figcaption class=\"uagb-image-caption\">Prof. Kristina Friedland and Prof. Kristina Endres from Johannes Gutenberg University Mainz, Germany. Picture Credits: Prof. Kristina Endres<\/figcaption><\/figure><\/div>\n\n\n\n<p><a href=\"https:\/\/www.unimedizin-mainz.de\/psychiatrie\/research\/research-groups\/endres-group.html?L=1\" target=\"_blank\" rel=\"noreferrer noopener\">Prof. Endres&#8217;s group<\/a> is interested in molecular pathways that interfere with the<b> <\/b>physiological and pathological processes of neuronal aging. The group analyses proteins characterized as longevity factors and\/or of neuro-protective property and their potential interplay with gaining resilience. Furthermore, the group focuses on molecular mechanisms of Alzheimer\u2019s disease, one of the major neurological diseases of the elderly.<\/p>\n\n\n\n<p>With the help of the research grant, Endres aims to assess mitochondrial function by investigating the expression of the enzymes of the respiratory chain and mitochondrial fission and fusion markers, e.g., DRP-1 and OPA1, after sampling of mitochondria by SS2000. In addition, they investigate mitochondrial biogenesis controlled by the transcription factors PGC-1\u03b1, PGC-1\u03b2, and NRF2. We wish Kirstina Endres and her group a lot of success with their research and hope we can contribute to ensuring the well-being of all.<\/p>\n\n\n\n<p>Please find the link to the news at Friedland lab: <a href=\"https:\/\/ak-friedland.pharmakologie.uni-mainz.de\/category\/allgemein\/\">Allgemein | Department of Pharmacology &amp; Toxicology (uni-mainz.de)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Finally, we present the winner of the first SS2000 Research Equipment Grant 2023. <\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/www.yokogawa.com\/eu\/blog\/life-innovation\/innovative-research-in-alzheimers-disease\/\"> <span class=\"screen-reader-text\">Innovative Research in Alzheimer&#8217;s Disease Powered by Yokogawa&#8217;s Single Cellome\u2122 System SS2000<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":78,"featured_media":1453,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","footnotes":""},"categories":[47],"tags":[],"coauthors":[117],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium 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As a product manager, I am responsible for the Yokogawa Life Innovation Business in Europe with the focus on our new Single Cellome Unit SU-10 and SS2000 as well as our confocal microscopy-based systems CSU-W1 and CSU-X1. Prior to joining Yokogawa, I was employed as a Scientific Researcher answering biological research questions by laser scanning confocal microscope techniques. 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