{"id":674,"date":"2021-11-02T14:13:22","date_gmt":"2021-11-02T13:13:22","guid":{"rendered":"https:\/\/staging.blogs.yokogawa.de\/life-innovation\/2021\/11\/02\/novel-tissue-imaging-profiling\/"},"modified":"2024-10-31T10:08:38","modified_gmt":"2024-10-31T09:08:38","slug":"novel-tissue-imaging-profiling","status":"publish","type":"post","link":"https:\/\/www.yokogawa.com\/eu\/blog\/life-innovation\/novel-tissue-imaging-profiling\/","title":{"rendered":"Novel tissue imaging, profiling and single cell sampling approaches"},"content":{"rendered":"\n

Why it’s important to analyze discrete locations of tissue<\/h2>\n\n\n\n

The detailed analysis of discrete locations of tissue is an important approach for the biomedical field. Useful information for understanding region-specific interaction between delivered drugs and host biomolecules can be provided from such analysis. Also, the drug distribution in different tissues can be estimated to understand better anti-microbial resistance.<\/p>\n\n\n\n

Resistance towards antibiotics<\/h2>\n\n\n\n

Unfortunately, in many cases, a disease is not beaten by developing a drug. After some time, bacteria can change themselves or get resistant to certain active ingredients. Thus, antibiotics are simultaneously a blessing and a curse. The resistance towards antibiotics is one of the most problematic issues in our modern society. The massive use of antibiotics leads to an increase in the resistance of bacteria towards antibiotics. For example, tuberculosis (TB) is the top ten cause of death worldwide which is caused by the mycobacterium tuberculosis and multi-drug resistant TB is a continued threat.<\/p>\n\n\n\n

\"tuberculosis
Incidence of tuberculosis worldwide in 2019, by region. Source: WHO<\/a><\/figcaption><\/figure>\n\n\n\n

What is Tuberculosis?<\/h2>\n\n\n\n

Tuberculosis disease is caused by the Mycobacterium tuberculosis (MTB) bacteria.  It is infectious and in 90% of all cases, the lungs are affected. It is a very insidious disease because in most cases there are no symptoms at first (latent tuberculosis)<\/em>. In 10 % of all latent tuberculosis cases, symptoms show at a later stage. If not treated, Tuberculosis disease can lead to death. Persons with active tuberculosis are contagious. The disease spreads by droplet infection (coughing, sneezing, speaking, or spitting).<\/p>\n\n\n\n

Symptoms of active Tuberculosis:<\/p>\n\n\n\n