Measuring the Electric Conductivity by use of Clean-in-Place (CIP) System


In the manufacturing process of Pharmaceutical, Chemical and Food & Beverage industries, the cleaning and sterilization of tanks and piping are done with various cleaning solutions, fresh or hot water and steam after manufacturing products. Clean- In-Place (CIP) is the system designed for automatic cleaning and disinfecting. The recovery of cleaning solutions contributes significantly to reduce chemical costs and wastewater processing costs.

Yokogawa FLXA202/FLXA21 inductive conductivity transmitter has earned a reputation in the recovery of cleaning solutions because it can take measurements with good boundary surface precision over a wide range.

CIP Process Flow

CIP Process Flow

Expected Benefits

  • Optimizes cleaning and sterilizing application for tanks and piping by use of CIP
  • Reduces operating costs

Process Overview

Inductive Conductivity SensorCIP systems depend on the process differentiations of Pharmaceutical, Chemical and Food & Beverage. In addition, the cleaning solutions and chemicals are different. The chemicals that are generally used are hypochlorous acid, caustic soda, and nitrous acid. In a cleaning solution recovery system, the process lines and piping are cleaned with an initial cleaning solution. After that, the cleaning solution is cleaned with fresh water. The cleaning solution is recovered at that point, but since it gradually becomes diluted with fresh water, recovery is discontinued and the solution is discharged through a drainage line when the concentration of the cleaning solution drops below the standard value. The cleaning with different solutions or fresh water, the recovery of the cleaning solution, and the discharge of waste solution are repeatedly carried out. In addition, sterilization with steam or cleaning with distilled water or de-ionized water is performed as a final step in some cases.

Solution Details

Measurement system
2-wire inductive conductivity system
Sensor ISC40G(J)
Flow-through type holder ISC40FF(J)
Transmitter FLXA202-D-B-D-AB-C5-NN-A-N-LA-J-NN
Dedicated distributor for transmitter PH201G-A☐*B


FLXA202 inductive conductivity transmitter
Power supply voltage: 17 - 40 V DC (from distributor)
PH201G distributor
Power supply: 100 V: 20 to130 V DC/80 to 138 V AC, 47 to 63 Hz
220 V: 120 to 340 V DC/138 to 264 V AC, 47 to 63 Hz
Power consumption: 24 V DC: approx. 200 mA
100 V AC: approx. 7 VA
220 V AC: approx. 11 VA


Temperature range of transmitter is -20 to 140°C

Field Data

1. Process Conditions

  Concentration (%) Temperature (°C) Pressure MPa
Water - 4 to 20 0 to 1
NaOH solution 1 to 5 80 to 90 0 to 1
HNO3 solution 1 to 5 80 to 90 0 to 1
Steam - below 130 0 to 1

2. Features of ISC Inductive Conductivity Meter used in a CIP Process

zero-suppression function
Zero-suppression function
  1. Improved precision in boundary surface measurement.
    (a) Equipped with a zero-suppression function according to output signal
    * Zero suppression
    Output: 4 to 20 mA DC
    Range: 100 to 300 mS/cm
    (b) One sensor can handle a minimum span of 100µS/cm and a maximum span of 1999 mS/cm.
  2. Steam sterilization capability
    Measurements can be performed at process solution temperatures of -10 to 130°C and pressures no greater than 2 MPa {20 kgf/cm2}


  • Chemical

    Chemical plants rely on continuous and batch production processes, each posing different requirements for a control system. A continuous process calls for a robust and stable control system that will not fail and cause the shutdown of a production line, whereas the emphasis with a batch process is on having a control system that allows great flexibility in making adjustments to formulas, procedures, and the like. Both kinds of systems need to be managed in available quality history of product, and to be able to execute non-routine operations. With its extensive product portfolio, experienced systems engineers, and global sales and service network, Yokogawa has a solution for every plant process.

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  • Food & Beverage

    At Yokogawa, we understand that today’s food and beverage companies face unprecedented challenges in climate change, consumer demand, and increased global competitiveness. Overcoming these challenges will require innovative solutions that focus on key areas of production, asset management, and food safety and quality.

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  • Pharmaceutical

    Pharmaceutical companies must achieve increased flexibility and agility through better use and monitoring of manufacturing data to improve quality management in real time. Pharmaceutical experts work with Yokogawa to create manufacturing solutions that deliver safe and reliable medicines. Together, we use digital transformation and manufacturing advances to meet regulatory requirements, ensure quality, accelerate time to market, and thus providing a stable and reliable supply of medicine to patient.

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  • Specialty & Fine Chemical

    Yokogawa has long served customers in the specialty and fine chemicals market. With a market leading batch solution that offers the best in class reliability and flexibility as well as industry experts who understand the complex requirements in designing a batch solution, you can be assured that in your partnership with Yokogawa you will have a system that will enable you to produce products that meet your customers’ needs in the future while maintaining safety and regulatory compliance.

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