Unlocking Life with Precision
Yokogawa’s sensitivity and precision solutions enable rapid and accurate measurements, empowering groundbreaking research, accelerating drug discovery, and optimizing bio-production at scale.
Image-Based Solutions
Image-based solutions for science and pharmaceutical drug development.
Yokogawa’s unique imaging designs and analysis tools improve sensitivity and speed for all your scientific exploration. Our instruments provide high-quality data, for maximized research goals.
Automated Instruments
Automated instruments accelerate research by streamlining routine life science tasks.
Yokogawa's automation tackles experimental overload, freeing researchers for more insightful questions and creative exploration. These systems can accelerate drug discovery, time to market, and scientific publication.
Digital Solutions
Digital solutions to monitor and consolidate complex pharmaceutical manufacturing processes.
Yokogawa's robust information sharing tools transcend conventional research organizations. They foster connections that drive problem-solving efficiency and overall experimental effectiveness.
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Spinning Disk Confocal CSU
Using our proprietary dual spinning disk design, Yokogawa’s confocal scanner units transform optical microscopes by enabling real-time live cell imaging.
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High Content Analysis CellVoyager
Our high-content analysis (HCA) systems utilize powerful software to address a wide range of research applications from basic science to complex compound screening.
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OpreX Informatics Manager
Yokogawa Electric's OpreX Informatics Manager is an information-integrated solution that goes beyond electronic lab notebooks by optimizing human and material resource management in terms of skills and scheduling.
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FlowCam: Flow Imaging Microscopy
With the FlowCam you can analyze particles accurately, reliably and quickly using automated imaging technology to advance your research, increase productivity, and ensure quality.
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Single-Cell Analysis Solutions Single Cellome™
We are developing cell handling technology for single-cell and live cells. SU10 provides selective, minimally damaging automated nano-point delivery. SS2000 provides automatically subcellular sampling based on confocal microscopy technology.
Details
Image-Based Solutions
Image-based solutions for science and pharmaceutical drug development.
Yokogawa’s unique imaging designs and analysis tools improve sensitivity and speed for all your scientific exploration. Our instruments provide high-quality data, for maximized research goals.
Automated Instruments
Automated instruments accelerate research by streamlining routine life science tasks.
Yokogawa's automation tackles experimental overload, freeing researchers for more insightful questions and creative exploration. These systems can accelerate drug discovery, time to market, and scientific publication.
Digital Solutions
Digital solutions to monitor and consolidate complex pharmaceutical manufacturing processes.
Yokogawa's robust information sharing tools transcend conventional research organizations. They foster connections that drive problem-solving efficiency and overall experimental effectiveness.
Yokogawa Life Science
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Erőforrások
Visualizing the cell behavioral basis of epithelial morphogenesis and epithelial cancer progression
Faster, Deeper, and Clearer -in vivo molecular imaging technology-
Discovering the Basic Principles of Life through the Live Imaging of C. elegans
Closing in on Neuronal Circuit Dynamics through High-speed, fMCI.
New Era in Manmmalian Genetics Research: To utilize the same embryo after long-time 3D observation!
Getting Closer to “Plant Cell World”with High-speed Live Imaging and Image Information Processing.
Spinning Disk Confocal Microscopy for Quantitative Imaging and Multi-Point Fluorescence Fluctuation Spectroscopy.
On-site manipulation of protein activities: Understanding intricate cell signaling pathways.
Use of the spinning disk confocal at the Harvard Medical School microscopy core.
In recent years, single cell analysis has become increasingly popular due to the new development of advanced and high sensitivity analytical methods.
SS2000 is a revolutionary system that can sample subcellular components and a whole cell by using a glass capillary tip with an inner diameter of a few μm while imaging with a confocal microscope.
This application note provides an example of single cell RNA sequencing scRNA seq) from cells sampled by SS2000, and the data is comparable to conventional methods.
In recent years, single-cell studies have become increasingly popular as analytical techniques have become more sensitive and widespread.
The SS2000 is a revolutionary device that can sample intracellular components and single cells using glass capillary tips with a diameter of several micrometers while performing confocal microscope imaging. These application notes introduce examples of sampling for various cell types.
In recent years, research on single cells has become increasingly popular. With more sensitive analytical techniques, it has become possible to analyze specific intracellular components such as organelles, even at the single-cell level.
The SS2000 is an innovative system that can sample subcellular intracellular components using a glass capillary having a tip diameter of only a few micrometers while imaging with a confocal microscope.
In this application note, we introduce a case where after drug treatment, intracellular components were sampled by the SS2000 and analyzed by single-cell mass spectrometry.
The SS2000 is a revolutionary system that allows both confocal imaging and sampling of targeted intracellular components or single cells using a glass tip with an inner diameter of a few micrometers. The SS2000 includes an incubator as well as highcontent imaging functions, such as long time-lapse observation, machine learning, and label-free analysis.
The SU10 is an innovative device that delivers target substances directly into cells or into nuclei with a nanopipette that has a tip outer diameter as small as a few tens nm.
This application note shows a case study of sampling and analysis with the SS2000 from cells delivered intracellularly with the SU10.
Comparison between CSU and conventional LSM in 4D movies.
In recent years, single-cell studies have become increasingly popular, leading to the development of instruments capable of spatial omics - the integration of samples' 3D locations and their omics data. The SS2000 is a revolutionary device that can collect intracellular components at the single-cell level and image the samples using a confocal microscope. In this application note we introduce the research performed by Dr. Okada of The University of Tokyo, who established an intra single living cell sequencing (iSC-seq) method which uses SS2000 to sample intracellular components from osteoclasts (a type of multinucleated giant cell) and analyzes them through next-generation sequencing.
To investigate interactive dynamics of the intracellular structures and organelles in the stomatal movement through live imaging technique, a CSU system was used to capture 3-dimensional images (XYZN) and time-laps images (XYT) of guard cells.
Cell stage categorized using FucciTime lapse imaging of Fucci-added Hela cells was conducted over 48 hrs at 1 hr intervals. Gating was performed based on the mean intensities of 488 nm and 561 nm for each cell. They were categorized into four stages, and the cell count for each was calculated.
The CV8000 nuclear translocation analysis software enables the analysis of changes in the localization of signal molecules that transfer between cytoplasm and nuclei, such as proteins. The following is an example of the translocation analysis of NFκB, a transcription factor.
Long-term observation of mitosis by live-cell microscopy is required for uncovering the role of Cohesin on compartmentalized nuclear architecture which is linked to nuclear functions.
To perform long term observation of mitosis devices are needed that have low phototoxic effects on living cells and enable high speed imaging. By using the CSU W-1 confocal scanner unit for time lapse imaging entrance into mitosis, mitotic progression and exit can be examined.
The CQ1 confocal image acquisition mechanism with the distinctive CSU® unit has a function to sequentially acquire fine cell images along the Z-axis and capture information from the entire thickness of
cells which include heterogenic populations of various cell cycle stages. In addition, saved digital images can be useful for precise observation and analysis of spatial distribution of intracellular molecules.
The CQ1 capability to seamlessly analyze images and obtain data for things such as cell population statistics to individual cell morphology will provide benefits for both basic research and drug discovery
targetingM-cell cycle phase.
- Colony Formation
- Scratch Wound
- Cytotoxicity
- Neurite Outgrowth
- Co-culture Analysis
- Cell Tracking
CV1000 clears the hurdle in Live Cell Imaging
All-in-one Live cell imaging solution
Faster, Brighter, and More Versatile Confocal Scanner Unit
Welcome to The New World of High Content Analysis
High-throughput Cytological Discovery System
Cell clusters are directly measured with high-throughput 3D imaging Confocal Quantitative Image Cytometer
Wide and Clear
Confocal Scanner Unit
In recent years, research on single cells has become increasingly popular, but with more sensitive analytical techniques, it has become possible to analyze specific intracellular components such as organelles at the single-cell level.
The SS2000 is an innovative system that can sample intracellular components at the single-cell level using a tip (glass capillary) with a diameter of several micrometers while imaging with a confocal microscope. In this application note, we introduce a case in which intracellular components were sampled by SS2000 and genetic analysis was performed by qPCR.
Fluorescent ubiquitination-based cell cycle indicator (Fucci) is a set of fluorescent probes which enables the visualization of cell cycle progression in living cells.
List of Selected Publications : CSU-W1
List of Selected Publications : CQ1
List of Selected Publications : CSU-X1
List of Selected Publications : CV8000, CV7000, CV6000
This "Tutorial" provides overview of this software, from installation through data analysis.
In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.
In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.
In this tutorial, spheroid diameter and cell (nuclei) count within the spheroid will be analyzed.
In this tutorial, we will learn how to perform time-lapse analysis of objects with little movement using CellPathfinder, through calcium imaging of iPS cell-derived cardiomyocytes.
In this tutorial, we will identify the cell cycles G1-phase, G2/M-phase, etc. using the intranuclear DNA content.
In this tutorial, image analysis of collapsing stress fibers will be performed, and concentration-dependence curves will be drawn for quantitative evaluation.
In this tutorial, we will observe the change in number and length of neurites due to nerve growth factor (NGF) stimulation in PC12 cells.
In this tutorial, intranuclear and intracytoplasmic NFκB will be measured and their ratios calculated, and a dose-response curve will be created.
In this tutorial, we will learn how to perform cell tracking with CellPathfinder through the analysis of test images.
In this tutorial, using images of zebrafish whose blood vessels are labeled with EGFP, tiling of the images and recognition of blood vessels within an arbitrary region will be explained.
Downloads
Brosúrák
- CQ1 Bulletin (21.1 MB)
Videók
The Yokogawa business vision states that the company endeavors to achieve Net-zero emissions, ensure the Well-being of all, and make a transition to a Circular Economy by 2050.
YOKOGAWA will contribute to technology evolution particularly in measurement and analytical tools to help build a world where researchers will increasingly focus on insightful interpretation of data, and advancing Life Science to benefit humanity.
YOKOGAWA aspires to establish Smart GMP manufacturing facilities that provide consistent quality and supply while eliminating industrial waste, enhancing productivity and always using high-quality component parts and materials.
YOKOGAWA creates autonomous operations with high-efficiency automation and optimization that allows growth with minimal deployment of manpower.
In this webinar, Professor Jonny Sexton discusses a pipeline, developed in the Sexton lab, for the quantitative high-throughput image-based screening of SARS-CoV-2 infection to identify potential antiviral mechanisms and allow selection of appropriate drug combinations to treat COVID-19. This webinar presents evidence that morphological profiling can robustly identify new potential therapeutics against SARS-CoV-2 infection as well as drugs that potentially worsen COVID-19 outcomes.
Hírek
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Sajtóközlemény jan 31, 2024 Yokogawa Introduces CellVoyager High-Content Analysis System CQ3000
- For greater efficiency in drug discovery and regenerative medicine R&D, and the swift commercialization of new drugs -
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Sajtóközlemény dec 1, 2021 Yokogawa Develops Single Cellome System SS2000 for Subcellular Sampling
A single-cell analysis solution that revolutionizes efficiency in drug discovery research by automating the collection of specific cells and intracellular components
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Sajtóközlemény dec 3, 2020 Yokogawa and InSphero Enter into Partnership Agreement
- Supporting drug development research through the use of HCA and three-dimensional culture models -
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Sajtóközlemény jn 22, 2023 Yokogawa to Release OpreX Informatics Manager, Enabling Integrated Management of Experimental Data and Research Resources in the Cloud
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Hírösszefoglalók pr 26, 2024 Yokogawa Helps to Revolutionize the Field of Single-Cell Lipidomics
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