CellVoyager High-Content Analysis System CQ3000

CellVoyager High-Content Analysis System CQ3000 can acquire high-resolution 3D images at high speed while culturing cells.
CQ3000 can be combined with options according to the intended use to provide a system depending on your objectives.

CQ3000 System Highlights

Excitation laser wavelength 405nm、488nm、561nm、640nm
Objective lens 2x、4x 、10x、20x 、40x、60x
(Dry 、Water immersion、Long working distance)
Camera High-sensitivity sCMOS camera (up to 2 units)
Autofocus Laser autofocus
Observation method Confocal image, Wide-field image*1
Software (Option) High Content Analysis Software CellPathfinder

*1 Can be acquired when Uniformizer option is selected.


Make way for high-performance HCA optimized for laboratories!

High NA immersion lens for high quality imaging, Uniformizer for uniform and efficient imaging of the entire FOV, and a second camera for simultaneous imaging of two channels can be selected according to the application.

Make way for high-performance HCA optimized for laboratories


High-resolution images that hold tons of information

  • Water immersion lens captures clear images with a high SNR.
  • In addition to fine observation via high magnification, it can accurately analyze images even with FOVs smaller than before due to the high-NA lens.
High-resolution images that hold tons of information

​​​​​Our high-NA 20x water immersion lens developed in-house allows for image resolutions higher than a 20x dry lens. You can use 40x and 60x for efficient image analysis.

Imaging example for a spheroid

​​​​​​Imaging example for a spheroid
20x WI lens allows for deeper imaging with high SNR.


High throughput imaging via simple operation

High throughput imaging via sample operation

​​​​​​Throughput comparison when using the 2nd camera option

​​​​​​Throughput comparison when using the 2nd camera option.
Detects two colors at the same time, so acquisition time is reduced.
In addition, if confocal performance is unnecessary such as during low magnification imaging, widefield imaging can further shorten the exposure time. 



When it comes to Yokogawa, it’s all about live-cell imaging

Live-cell imaging

CQ3000 achieves culturing and imaging while maintaining the same environment as a conventional CO2 incubator.
It’s not only environmentally friendly, but it also minimizes the impact on cells.


Analysis software : High content analysis system CellPathfinder(Option)

The intuitive, easy-to-use interface guides the user from analyzing thousands of image data in various angles to visualize the result by generating numerous graph types.
In addition, the Machine Learning and Deep Learning function increase the target recognition capability dramatically. It is also ideal for the analysis with the complexity and high-degree-of-difficulty such as analyzing the data from 3D culture and live-cell imaging.
The CellPathfinder software is a powerful tool for HCA.


Click Here For More Info!

Machine learning

Software learns the features of the sample objects collected by users.

3D analysis


Label-free analysis

Wide-field*1 function is a powerful tool to analyze unstained bright field samples.


*1 Can be acquired when Uniformizer option is selected.


Optics Microlens enhanced dual wide Nipkow disk confocal, Transmitted illumination

Laser : Up to 4 colors  Standard : 488 nm, 561 nm Option : 405 nm, 640 nm
    High power lasers Option : 488 nm, 561 nm
EM filter : Max. 10 filters (including 1 filter for transillumination)
Observation method : Confocal image, Wide-field image*1

Transmitted illumination Bright-field  LED light 
Camera High-sensitivity sCMOS
Max. 2 units, simultaneous excitation of 2 wavelengths
Number of effective pixels : 2000 x 2000 pixels
Field of view size: 13.0 x 13.0 mm
Objective lens Max. 6 lenses (Included max. 2 water immersion lenses)
Dry : 2x, 4x, 10x, 20x, 40x , 60x Long working distance : 20x, 40x Water immersion: 20x, 40x, 60x
Water supply function for immersion lens Automatic supply
Flat-top beam shaper(Option) Uniformizer
Sample vessel Microplate (6, 12, 24, 48, 96, 384, 1536 wells), glass slides*2, cover glass chamber*2, 35 mm dish*2
Stage incubator Temperature control range 35 ~ 39 °C  Settable temperature resolution : 0.1 °C
Time stability : ±0.2 °C Spatial stability : ±1 °C (at an ambient temperature of 21 ~ 25 °C)
Humidity holding
Automatic water supply function for incubator
Autofocus Laser autofocus, Image-based autofocus
Fast time-lapse (Option) Max.100fps, Simultaneous dual wavelength excitation imaging
Analysis software(CellPathfinder) Granule analysis, Neurite analysis, Nuclear morphology analysis, Nuclear translocation analysis, Membrane translocation analysis, Machine learning, Label-free analysis, 3D analysis, Texture analysis, Deep Learning, etc.
Other features Self-diagnosis function, CQ Analysis
Size・Weight Main unit W1031 mm x D401 mm x H600 m 84 kg
Main unit (with Uniformizer or 2nd camera) W1177 mm x D401 mm x H600 mm 102 kg
Utility box W275 mm x D432 mm x H298 mm 17.6 kg
Gas mixer W275 mm x D432 mm x H298 mm 9.3 kg
Workstation W176.5 mm x D452.1 mm x H417.9 mm 21.7 kg
Operating environment 15 ~ 30°C, 30 ~ 70% RH, no condensation
Power consumption Main unit and Utility box : 100 - 240 VAC, 400 VAMax
Gas Mixer : 100 - 240 VAC, 60 VAMax
Workstation : 100 - 240 VAC, 750 VAMax

*1 Can be acquired when Uniformizer option is selected.
*2 Sample Holder option is needed.

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  • CellActivision

    CellActivision uses Machine Learning Technology and a unique digital filter to recognise cells or colonies directly from label free images. CellActivision can also classify and quantify these cells by the use of sample libraries which are easily prepared by the user.

    See More
  • CellPathfinder

    CellPathfinder is designed for our HCA systems, CQ1 and the CellVoyager series. From beginners to experts, the analysis software lets you quantify subtle physiological changes and even label-free samples with various graph options.

    See More




YOKOGAWA will contribute to technology evolution particularly in measurement and analytical tools to help build a world where researchers will increasingly focus on insightful interpretation of data, and advancing Life Science to benefit humanity.


In this webinar, Professor Jonny Sexton discusses a pipeline, developed in the Sexton lab, for the quantitative high-throughput image-based screening of SARS-CoV-2 infection to identify potential antiviral mechanisms and allow selection of appropriate drug combinations to treat COVID-19. This webinar presents evidence that morphological profiling can robustly identify new potential therapeutics against SARS-CoV-2 infection as well as drugs that potentially worsen COVID-19 outcomes.


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