Houston, Texas– September 16, 2025
Yokogawa Corporation of America
Repligen Corporation
Yokogawa Corporation of America and Repligen announce a collaboration to integrate Yokogawa’s OpreX Bio Pilot with Repligen’s MAVERICK®, enhancing automated control of glucose and lactate levels in cell cultures. The combination of these solutions allows scientists in process development to measure critical process parameters in bioprocessing without building complicated calibration models. This integration enables continuous, real-time analysis without manual sampling and supports effective data management.
In the field of bioprocessing, the continuous monitoring of glucose and lactate levels is crucial for optimizing cell culture conditions and thereby the research and development of biopharmaceutical products. Accurate measurement of these parameters allows for better control of the bioreactor environment, minimizing batch failures, leading to improved productivity and reduced time to market.
The initial scientific data from this collaboration bridging real-time analytics and intelligent, digital bioprocessing will be presented by Yokogawa during the forthcoming BioProcess International on September 17th, 2025. The combined solution is currently being demonstrated at both Yokogawa Electric Corporation’s laboratory in Tokyo, Japan and Repligen’s facility in Waltham, MA. Additional studies are planned at these laboratories and other institutions.
Mai Hagimoto, Life Sciences Director at Yokogawa Corporation of America, stated, “We are thrilled about this partnership, which represents a significant advancement in bioprocess automation. By integrating MAVERICK with OpreX Bio Pilot, we are enabling real-time, in-line monitoring of critical process parameters with unprecedented accuracy and efficiency. This joint solution simplifies complex analytical workflows and supports data-driven decision-making in cell culture optimization. We are confident that this innovation will contribute meaningfully to accelerating biopharmaceutical development and enhancing operational excellence across the industry.”
“Empowering our biopharma customers with cutting-edge solutions is at the heart of the partnership with Yokogawa,” explains Chris Brown, VP Research & Development Analytics of Repligen. “The team clearly recognizes the power of modern bioprocess analytics for control of critical bioprocess parameters, and acceleration of development workflows. We have worked intensely to provide highly differentiated capability with MAVERICK®. It is the first Raman-based product that is turn-key and built for bioprocess analytics, and the Yokogawa team was very quick to see the advantages of incorporating this platform in their automation solution.”
About OpreX Bio Pilot
OpreX Bio Pilot is a user-friendly, all-in-one integration and automation tool designed to address the complex challenges of bioprocessing. It seamlessly integrates bioprocess instruments from multiple vendors across various protocols. Real-time data collection from PAT equipment enables advanced analysis and control, while automation of daily and manual operations is supported with an intuitive, easy-to-build flowchart interface.
About Yokogawa
Yokogawa provides advanced solutions in the areas of measurement, control, and information to customers across a broad range of industries, including energy, chemicals, materials, pharmaceuticals, and food. Yokogawa addresses customer issues regarding the optimization of production, assets, and the supply chain with the effective application of digital technologies, enabling the transition to autonomous operations.
Founded in Tokyo in 1915, Yokogawa continues to work toward a sustainable society through its 17,000+ employees in a global network of 128 companies spanning 62 countries.
For more information, visit www.yokogawa.com
About Repligen Corporation
Repligen Corporation is a global life sciences company that develops and commercializes highly innovative bioprocessing technologies and systems that enable efficiencies in the process of manufacturing biological drugs. We are “inspiring advances in bioprocessing” for the customers we serve; primarily biopharmaceutical drug developers and contract development and manufacturing organizations (CDMOs) worldwide. Our focus areas are Filtration and Fluid Management, Chromatography, Process Analytics and Proteins. Our corporate headquarters are located in Waltham, Massachusetts, and the majority of our manufacturing sites are in the U.S., with additional key sites in Estonia, France, Germany, Ireland, the Netherlands and Sweden. For more information about the company see our website at www.repligen.com, and follow us on LinkedIn.
Media Contact
Yokogawa Corporation of America
Christie Cronje
PR and Corporate Communications Manager
christie.cronje@yokogawa.com
The names of corporations, organizations, products, services, and logos herein are either registered trademarks or trademarks of Repligen Corporation, Yokogawa Electric Corporation or their respective holders.