Yokogawa Launches Single Cellome System SS2000 in Europe

Yokogawa Deutschland GmbH announces the official launch of the Single CellomeTM System SS2000 in Europe. This solution utilizes high-resolution images captured with a confocal microscope to automatically and accurately collect samples of specific cells and intracellular components. The Single Cellome System SS2000 has received the CE marking and the UKCA marking.

Development Background

As the smallest unit of all living organisms, cells can greatly differ from one another; hence, there is a growing focus on single-cell analysis involving the isolation and handling of individual cells, as opposed to studying a population. In recent years, with improved analytical technology, it has become possible to analyze not only single cells but also specific molecules within them. Understanding the characteristics and functions of cells and mechanisms for cell development is a very effective means for clarifying the causes of diseases, preventing them, and verifying the efficacy of new drugs. This is essential for drug discovery research and the development of precision medicine and regenerative medicine.

Conventional techniques for the analysis of intracellular components have typically involved the disruption and collection of heterogeneous cell populations, which does not allow for sampling at the individual cell level, so many components cannot be collected and essential information on cell location and morphology is lost. In addition, as this sampling is done manually, throughput is low, and it is quite difficult for even experienced researchers.

Utilizing Yokogawa's core imaging technologies that enable the real-time analysis of minute phenomena in live cells, the Single Cellome System SS2000 incorporates new technologies that automatically and accurately control sampling operations in order to support the performance of cutting-edge life science research.

Features

Yokogawa confocal microscopy technology enables the rapid, minimally invasive imaging of living cells. Based on the high-sensitivity analysis of the high-resolution 3D images, the cells are automatically and precisely sampled using precise positioning technology.

  1. Optimal selection of cells or regions within cells according to set criteria
    The Single Cellome System SS2000 analyzes images of a large number of cells within a target range and classifies them by using provided criteria such as cytoplasm area and nucleus size. It then identifies which cells are suitable for analysis and determines their sampling location. Utilizing criteria such as distance from the nucleus, image analysis can even identify optimal regions within individual cells.
  2. Reliable sampling of target cells and components within individual cells
    The Single Cellome System SS2000 directly samples only target cells without detachment, retaining all positional and morphology information in the culture plate. Furthermore, the utilization of high-resolution 3D images and precise positioning technology enables the selective sampling of target organelles and cytoplasm.

    Subcellular sampling: After staining of HeLa cell nuclei (blue), cytoplasm (green), and mitochondria (red), a mitochondria-rich region (arrow) of the cytoplasm was sampled.
  3. Samples can be used for a broad range of analyses
    The collected cells and intracellular components can be used for a broad range of analyses, including genetic analysis and mass spectrometry. The optimum and efficient collection of target samples improves analytical sensitivity. In addition, single living cells that have been sampled can be grown in secondary cell cultures.

Main Applications

For more information

Single Cellome System SS2000 webpage: www.yokogawa.com/eu/solutions/products-platforms/life-science/single-cellome/ss2000/
Video: www.yokogawa.com/eu/library/videos/product-overviews/single-cellome-system-ss2000-for-subcellular-sampling/

About Yokogawa’s life science portfolio

Yokogawa’s life science business started in 1996 with the development of innovative instruments based on proprietary confocal microscopy technologies, and is dedicated to providing novel products employing microscopy and/or image analysis technology for the advancement of cell biology research and drug discovery. The company’s portfolio includes the Confocal Spinning Disk Unit (CSU), CellVoyager™ High Content Analysis Systems and Software, and the new Single Cellome™ portfolio for nano-point delivery and subcellular sampling. For more information, visit www.yokogawa.com/eu/solutions/products-platforms/life-science/#Overview

About Yokogawa

Yokogawa provides advanced solutions in the areas of measurement, control, and information to customers across a broad range of industries, including energy, chemicals, materials, pharmaceuticals, and food. Yokogawa addresses customer issues regarding the optimization of production, assets, and the supply chain with the effective application of digital technologies, enabling the transition to autonomous operations. Founded in Tokyo in 1915, Yokogawa continues to work toward a sustainable society through its 17,000+ employees in a global network of 122 companies spanning 61 countries.

About Yokogawa Europe B.V.

The European headquarters of Yokogawa were founded in Amersfoort in the Netherlands in 1982. Throughout Europe Yokogawa has its own sales, service, and engineering operations. This dedicated network has been extended to Central and East Europe to further enhance the coverage and support associated with serving the process control and automation marketplace. Yokogawa develops and produces flowmeters at Rota Yokogawa in Germany and liquid analyzers and industrial safety systems in the Netherlands. In addition to the network of Yokogawa subsidiaries, a select number of Channel Partners are available in certain areas to support specific customer needs of this continuously developing market.
For more information, visit www.Yokogawa.com/eu

The names of corporations, organizations, products, services and logos herein are either registered trademarks or trademarks of Yokogawa Electric Corporation or their respective holders.

Media Contact Information

For further questions, please contact Diana Corcalea (diana.cocarlea@ro.yokogawa.com) or lifeinnovation@de.yokogawa.com.

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    The Single Cellome™ System 2000 is a system that automatically samples specific regions of cells or whole cells at the single-cell level while imaging cells in culture with a confocal microscope. Because cells in culture do not need to be detached, positional and morphological information is maintained.

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