Yokogawa Deutschland GmbH announces the official launch of the SU10 Single CellomeTM Unit in Europe. The SU10 uses a nanopipette*1 to deliver substances such as gene editing tools or reagents at targeted locations in individual cells.
The SU10 Single Cellome Unit
The SU10 is the perfect tool for live cell manipulation, and complements Yokogawa’s live cell imaging portfolio. Through the development of such solutions, Yokogawa’s Life business is fostering the development of an industry centering on the use of smart cells, i.e. finely-designed, expression-controlled biological cells.
Development Background
Rapid advances in biotechnology are leading to the development of a bioeconomy that is expected to have a wide impact on fields ranging from agriculture to manufacturing and healthcare.
In cancer and immunology research fields, single-cell analysis helps to clarify the causes of diseases and study pathological conditions. This is expected to lead to advances in drug discovery research and the development of personalized medicine and regenerative medicine. With the aim of fostering the development of a smart cell industry, Yokogawa has developed the SU10 for use by researchers in single-cell manipulation.
Features
- Single-cell targeting
The SU10 can directly deliver reagents into a selected single cell. - Minimally invasive*2 nanopipette
The SU10 enables the delivery of substances such as gene editing tools or drugs at targeted locations in individual cells. In contrast to the micrometer-sized pipettes that are used to perform such tasks, the tip of the nanopipette used in the SU10 has a minimum outer diameter of several tens of nanometers (nm). It is one of the smallest pipettes available for use in the biology research field*3. The tip of this nanopipette is much smaller than the cells that are penetrated with the SU10, making it minimally invasive and thereby allowing single-cell manipulation of living cells. - Improved efficiency through automation of the delivery process
An industry first*4, the SU10 automates a series of processes, starting with the detection of a cell surface and continuing with the penetration of the cell surface and the delivery of materials into the cell. These are all operations that until now had to be performed manually by skilled researchers. With the SU10, delivery and sampling*5 operations can be performed easily on living cells.
Nano delivery process
Major Target Users
● Universities, and research institutes that engage in life science research
● Pharmaceutical and food companies
Main Applications
● Delivery of genome-editing tools (e.g. Cas 9 protein / sgRNA RNP) directly into the nucleus
● Delivery into cells that cannot be introduced by conventional methods (e.g. plant cells, primary cells)
● Evaluation of efficacy and toxicity of drug candidate molecules
● Analysis of cell-cell communication by combining with live cell imaging tech
Delivery of genome editing tools directly into the nucleus
Delivery into cells that cannot be introduced by conventional methods
Efficacy/toxicity evaluation of drug candidate molecules
Analysis of cell-cell communication starting from the injected cell
Outlook
“Single-cell analysis enables the reconstitution of information regarding the causes of genetic changes, and it can contribute to studies on the molecular basis of cell transformation and proliferation.
Dr. Erika Zernickel, Product Manager SU10”
*1 A pipette is a tube for injecting and sampling*5 a minute amount of material. A nanopipette is a tube with a tip diameter from 1 nanometer (nm) to less than 1,000 nm. One nm is equal to one-billionth of a meter. The term nanopipette also refers to a tube whose delivery/sampling*5 volume is nanosized.
*2 Not causing much physical damage to a living organism. This term is used in the medical and biological fields.
*3 One micrometer (μm) is equal to one millionth of a meter, and one nanometer (nm) is equal to one billionth of a meter.
*4 Based on a March 2020 Yokogawa survey.
*5 Sampling function to collect intracellular materials is under development.
For more information
https://www.yokogawa.com/eu/solutions/products-platforms/life-science/single-cellome/su10/
About Yokogawa
Yokogawa provides advanced solutions in the areas of measurement, control, and information to customers across a broad range of industries, including energy, chemicals, materials, pharmaceuticals, and food. Yokogawa addresses customer issues regarding the optimization of production, assets, and the supply chain with the effective application of digital technologies, enabling the transition to autonomous operations.
Founded in Tokyo in 1915, Yokogawa continues to work toward a sustainable society through its 17,500 employees in a global network of 119 companies spanning 61 countries.
For more information, visit www.yokogawa.com
About Yokogawa Europe B.V.
The European headquarters of Yokogawa were founded in Amersfoort in the Netherlands in 1982. Throughout Europe Yokogawa has its own sales, service and engineering operations. This dedicated network has been extended to Central and East Europe to further enhance the coverage and support associated with serving the process control and automation marketplace. Yokogawa develops and produces flowmeters at Rota Yokogawa in Germany and liquid analyzers and industrial safety systems in the Netherlands. In addition to this dedicated network of Yokogawa subsidiaries, a select number of Channel Partners is established in certain areas to support specific customer needs of this continuously developing market.
Contact Information
For further questions, please contact Mailyn Schürmann (mailyn.schuermann@de.yokogawa.com) or lifeinnovation@de.yokogawa.com