Advanced Control Bioreactor System BR1000

The Advanced Control Bioreactor System BR1000 automates lab-scale mammalian cell culture with highly accurate real-time monitoring and advanced process control.

In-line sensor for measuring glucose and lactate concentrations

Based on YOKOGAWA's original calibration model and instrumentation, the concentration of glucose and lactic acid in the culture medium can be measured in real-time and with high accuracy based on the absorption characteristics of near-infrared light.

Glucose concentration

Glucose concentration in culture

Lactate concentration in culture

In-line sensor to measure live cell density

Based on YOKOGAWA's original calibration model, the live cell density can be measured in real time from changes in the capacitance characteristics of the cell suspension. The unique calibration model also maintains high accuracy throughout the entire cell culture timeline, from seeding to high cell densities.

 live cell density

 live cell density

Soft sensor for estimating glucose consumption rates in real time

A model prediction and control algorithm processes the data obtained by the in-line sensors and outputs a highly accurate glucose consumption rate trend in real time.

Rate of specific glucose consumption and specific lactate generation

Advanced control to automatically control glucose concentration

An advanced control algorithm designed specifically for cell culture provides accurate and automatic control of glucose based on in-line sensor values. Peristaltic pump systems dynamically deliver sterile glucose solution as needed to maintain the glucose set-point concentration value.

Glucose concentration


Glucose concentration


Features of the system

The instrument provides basic control of pH, temperature, and dissolved oxygen, a near-infrared sensor for monitoring cell activity, a viable cell density sensor, feed control, and data logger, all integrated into one complete system.

Extensive control functions and ease of use

Automated Cell Culture

The bioreactor system provides advanced process control driven by innovative hardware and software technologies to improve reproducibility and stability of cell culture conditions for better biopharmaceuticals.

Customization and remote support (optional)

Comes complete with a calibration model derivation tool that customizes and improves the accuracy of in-line sensors.
Provides the capability for real-time remote monitoring in a networked environment.

Control software

Trend Data

Remote monitoring (Optional)


Model number BR1000
Working volume 1-5L
Liquid delivery pump Number of channels: 4/6
Stirrer control Control range: 4-200rpm
Temperature control Control range: 34-40℃
pH control Control range: 6.5-7.5
Dissolved oxygen control Control range: 1-5mg/L
In-line measurement of glucose concentration Measurement range: 0-10.0g/L
In-line measurement of lactate concentration Measurement range: 0-10.0g/L
In-line measurement of viable cell density Measurement range: 1×105-1×108cells/mL
Other standard functions Culture vessel (cell culture medium) weight monitor, Feed bottle weight monitor, Automation control disengagement button
User interface Touch panel monitor
Log data file format Custom file record format (GM10) (*.GSD *GEV)
Classification of laser product Class 1 Laser Product (IEC 60825-1:2007/2014)
Operating environment 20 to 26℃, 20 to 80%RH without condensation, Altitude ≦ 1000m
Power supply Single phase 100/115/200/230VAC, 50/60Hz, Rated power: 500W
External dimentions 400(W)×750(D)×1650(H)mm
Weight 175kg




Our approach is to leverage state-of-the-art technologies for real-time monitoring and predictive control that allow virtual environments where "digital twin" processes can provide distinct advantages.


Looking for more information on our people, technology and solutions?

Contact Us