Pharmaceutical companies must achieve increased flexibility and agility through better use and monitoring of manufacturing data to improve quality management in real time. Pharmaceutical experts work with Yokogawa to create manufacturing solutions that deliver safe and reliable medicines. Together, we use digital transformation and manufacturing advances to meet regulatory requirements, ensure quality, accelerate time to market, and thus providing a stable and reliable supply of medicine to patient.
Optimized
Operation
Pharmaceutical companies succeed by delivering quality medicines on time. This requires optimizing operations, integrating systems, digitalizing data, and establishing continuous improvement. A smart factory optimizes the entire facility, leveraging customer and process strengths.
Consistent
Quality
Quality assurance requires dedication in managing data, maintaining accuracy, and meeting regulatory requirements. Yokogawa provides tools, workflows, and user-defined access to support these goals, allowing teams to track progress and manage deviations efficiently.
Time to
Market Acceleration
Pharmaceutical companies seek to accelerate the development process. Yokogawa offers a complete solution that links the chemistry, manufacturing, and controls (CMC) areas with other areas of the facility. Using Yokogawa solutions, customers reduce the lead time from development to production.
Bridging the Drug Discovery to Production
Biotechnology and drug development technologies are advancing daily. The progression of biotechnology and the efficiency of research support the creation of continuous innovations that challenge unmet medical needs.
Digital Transformation
The pharmaceutical industry faces a dilemma of balancing rising compliance costs for quality assurance with the imperative to generate profits. Yokogawa aims to overcome this challenge by implementing elements of Pharma 4.0, offering significant long-term benefits.
Well-being
All patients should have access to safe and reliable medication. Our co-innovations contribute to a future embracing global harmony by helping to ensure a stable and efficient supply of high-quality, safe pharmaceuticals.
Upcoming Events
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Conference Jul 22, 2024 - Dec 31, 2027 Singapore, Indonesia, Malaysia, Philippines, Thailand, Taiwan, Australia & New Zealand, VietnamSustainability Assessment (COSIRI) – Guided Pathway towards Sustainable Food Manufacturing
The Sustainability Assessment COSIRI -Guided pathway towards Sustainable Food Manufacturing was featured in the Yokogawa Philippines Food and Beverage _Modernerization and Innovation Summit-Exhibition-22-23May2024. Learn about Sustainability Assessment enables food factories to formally assess their current level of sustainability. The assessments provide companies with invaluable insights into risk and gaps and what can be done to improve their standing. To help food companies pace their sustainability initiatives, the assessment provides a benchmark of company’s position against industry peers. # Decarbonisation #SustainabilityAssessment
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Conference Nov 26, 2024 - Dec 31, 2026 Manila, Philippines6th Philippines Railway Summit: Enhancing Railway Safety: Addressing Occupational Hazards with Yokogawa RAP
Yokogawa's technology for innovation and technology in the railway industry.
This event highlights Yokogawa’s commitment to supporting government initiatives in expanding the rail footprint through modernization and advanced technologies. From infrastructure upgrades to smart transport solutions, we’re dedicated to driving operational excellence, enhancing safety, and building a sustainable future for rail.
Details
Optimized Operation
Data sharing is crucial for accelerating automation and optimization, reducing downtime, and improving efficiency in delivering high-quality medicines. Yokogawa's well-designed solutions gather and deliver data throughout the organization, supporting an interconnected and automated factory. They integrate digital technologies and enable seamless integration of measurement, control, and systems solutions. Throughout the product lifecycle, data remains complete and accurate.
Measurement
Accurate measurements and secure data recorders are essential for a solid foundation. Knowledge of sensing technology is crucial for industrial and engineering fields. Analytical sensors are key to creating value. The challenge is to move from sensing to adding value to data. To improve profitability and sustainability, collecting a wider range of sensor data or using highly accurate plant data is necessary.
Analysis
Reduce inefficiencies that lead to increased work hours and production losses. Improve process data analysis and avoid losses. Promote optimal control and realize Pharma 4.0 where products are made continuously, and multiple devices move simultaneously while adhering to the regulations.
Integration
Find efficient tools that enable access and analysis of data scattered across the company to arrive at well-informed decisions. Reduce shutdowns due to unexpected breakdowns while reducing unnecessary maintenance activities.
Consistent Quality
Yokogawa supports quality groups in managing data, ensuring accuracy and regulatory compliance, and understands the importance of following SOPs regardless of experience. With reliable processes and controls, success is achieved. Yokogawa works with pharmaceutical partners to prevent mistakes and prioritize quality by minimizing errors and contamination, and using approved manufacturing systems.
Time to Market Acceleration
Pharmaceutical manufacturers aim to meet medical needs by creating and delivering innovative drugs. Yokogawa co-innovates with customers to provide technologies like digital twins and streamline data sharing for labs, trials, and manufacturing.
Resources
- Highlyadvanced biopharmaceutical plant uses CENTUM, VP Batch, Exaquantum and PRM.
- Total system integration for large-scale biotech production facility.
- Yokogawa provides CENTUM VP with Batch Recipe Management Package for new fine chemical plant.
- Yokogawa's CENTUM VP complies with the requirement of Good Automation Manufacturing Practices(GAMP).
- Uninterrupted Medical Oxygen Production with FAST/TOOLS Monitoring.
- Audits are performed periodically, requiring traceability and the keeping of historical records for all batch production activities.
- RotaMASS was chosen to work with weight measurements and/or differential pressure transmitters for extremely accurate measurements.
- The customer recognized the product's advantages: reliability, accuracy, guaranteed draining system, easily cleaned system, no moving parts, directly built into the pipelines, low pressure losses.
Kyowa Hakko Bio monitors vibration trends with Yokogawa's Sushi Sensors to prevent unexpected equipment failures.
By using eServ, sensor data and maintenance information are shared with everyone involved in manufacturing.
Bushu Pharmaceuticals, Ltd., a major contract manufacturing company, is working to eliminate human error to ensure the integrity of test results data, and to promote reliable inspections and paperless operations.
Establish thorough quality assurance with state-of-the-art facilities and technologies to foster the future of medical products.
At Shionogi, the facility maintenance management system eHOZEN, the pr edecessor of eServ, has been used for about 10 years. However, due to the aging of servers and systems, they have begun considering renewing the system with the latest one. When considering this, suggestions from several vendors were received assuming that the system package safely migrates data assets accumulated on the current server and meets the following requirements:
The introduction of eServ has resulted in a centralized system of facility information. The reason for the loss of production opportunities has become clear, and it has become possible for all members to follow up the progress of the measures.
Wide and Clear
Confocal Scanner Unit
When used to measure the dissolved oxygen in an aeration tank, sensors tend to quickly become contaminated and need frequent cleaning. A cost-effective solution to this problem has finally been found with the development of the Yokogawa DO402 Dissolved Oxygen Converter system.
- For remote monitoring (of temperature, pressure, and flow volume), installing the SMARTDAC+ GM in the plant and the SMARTDAC+ GX in the office provides for a scalable, pc-free on-site data monitoring solution.
- You can centralize management of large quantities of data by automatically transferring acquired data to a FTP server.
The discharge of improperly treated industrial chemicals and fuel gas can have a major impact on the environment, posing a serious threat to public health. Concurrent with the global growth of manufacturing operations to keep pace with market trends, many countries are taking measures to deal with environmental problems.
For the management of raw materials in the pharmaceutical and cosmetics industries, a manual titration method presents many difficulties. Yokogawa developed the NR800 FT-NIR Analyzer, and with this system, measurements are reliable and stable. It is much easier to control quality.
Cell stage categorized using FucciTime lapse imaging of Fucci-added Hela cells was conducted over 48 hrs at 1 hr intervals. Gating was performed based on the mean intensities of 488 nm and 561 nm for each cell. They were categorized into four stages, and the cell count for each was calculated.
Faster, Brighter, and More Versatile Confocal Scanner Unit
- Colony Formation
- Scratch Wound
- Cytotoxicity
- Neurite Outgrowth
- Co-culture Analysis
- Cell Tracking
Eliminating the wire using wireless transmitter is the perfect solution for rotating equipment. It establishes data collection between the transmitter and the gateway by reliable communication even though the dryer was rotating.
SMARTDAC+ GX series records the clean room temperature, humidity, atmospheric pressure, door openings and closings, etc.
This introduces a system that uses Ethernet communications to acquire measured values, target values, and control output values from a controller installed on site into a PLC at high speed (ten units' worth within one second).
In semiconductor manufacturing processes, a deficient clean room environment can lead to defects and wasted resources, making a strictly controlled clean room indispensable. Maintaining the environment in the clean room requires control of air filters, HVAC systems, room temperature, humidity, airborne particles, and other factors.
In the plants of food and beverage manufacturers, there are times when monitoring and recording of production equipment is necessary inside clean rooms. This is an introduction to monitoring and recording in clean rooms using paperless recorders.
Performing control while changing the set point temperature moment by moment is called running a program pattern (or simply running a program). Sterilization and pasteurization require maintaining specific temperatures for specific durations.
The paperless recorder DX series automatically calculate the Fo value from the heating temperature and are useful in managing the sterilization process by displaying and recording the value together with the heating temperature.
In the manufacturing process of Pharmaceutical, Chemical and Food & Beverage industries, the cleaning and sterilization of tanks and piping are done with various cleaning solutions, fresh or hot water and steam after manufacturing products. Clean-In-Place (CIP) is the system designed for automatic cleaning and disinfecting.
What if you could detect signs of abnormalities in bus ducts (bus bars) quickly during maintenance and inspection work and respond to them at just the right time? Yokogawa DTSX monitoring solution constantly monitors connections that tend to deteriorate over time and contributes by pinpointing abnormality locations and reducing workload of maintenance personnel, helping to ensure stability in plant operations.
By using the Multibatch function (an option added with SMARTDAC+), you can efficiently record data from multiple devices onto a single SMARTDAC+.
Using the custom display function that comes standard with DXAdvanced means that you can combine the recorders, displays, and switches used in various kinds of equipment.
Using the batch name + lot number system, past measured data can be recalled for reference by batch name.
- Universal inputs provide support for thermocouple, RTD, voltage, and a variety of other input signals.
- Lineup of models for up to 450 inputs.
Allows multipoint monitoring and recording on a single unit. - Easily enables network-based data management.
file transfers, Web monitoring, and alarm e-mail
By using the computation function of the SMARTDAC+ series Paperless recorder GX/GP, computation option computes the "F-value," or sterilizing value for the sterilization process, so that the computation results can be recorded in the form of data.
The sterilization temperature prior to the filling process is monitored in the field or office. The temperature data is recorded in an external storage medium.
Blending plays a key role in industries such as food, healthcare and chemicals etc. Temperature and vacuum measurements are very important in minimizing the moisture content to ensure the quality of the final product. Strictly maintaining them throughout the process ensures the final product yield.
One of the primary applications for high purity water is for boiler feed water. The measurement of pure water pH can be one of the quickest indicators of process contamination in the production or distribution of pure water. Effective chemical treatment of the feed water is vital in maintaining the useful operating life and minimizing maintenance costs of the boiler.
With industrial and economic development comes increasingly large and advanced power plants and factories. Nevertheless, we find many cases where the original cables, cable tunnels, and other components of the power infrastructure have languished under continuous operation.
This technical white paper will discuss Yokogawa's CENTUM VP DCS (Distributed Control System) product, hereafter referred to as "CENTUM VP", and the extent of its compliance with Part 11 of Title 21 of the Code of Federal Regulations, (21 CFR Part 11), the Electronic Records / Electronic Signatures Rule.
The worlds of process automation and production management have been converging for some time. What once used to be islands of automation and production management functionality connected through highly proprietary integration schemes that were costly to maintain have developed into integrated platforms that provide seamless data exchange between the world of automation and the plant floor, the functions of production and operations management, and integration with business level systems.
The world of process automation is governed by procedures. While we like to refer to the process industries as being largely "continuous", this could not be further from the truth. Process manufacturing is constantly in flux.
From engineering to installation, commissioning, operations, and maintenance, FOUNDATION fieldbus offer significant cost reductions of 30 percent or more versus conventional analog systems. Many of these cost reductions come from the advanced functions that fieldbus offers versus analog technology.
This document describes the operation and data flow of the Yokogawa Print Wave software using the DX-P Reporter. It will provide a detailed explanation of the Advanced Alarm Reporter functions. The functions described in this paper were first released in Print Wave version 5.5.
Discovering your Baseline with OT Security Risk Assessment
The first stage in creating next-generation production control system that achieves innovative plant operation is providing "Visualized operation". "Visualized operation" for the customer means that he can reliably access and visualize plant data regardless of plant location and time.
Lonza's Riverside plant manufactures bulk active ingredients for the pharmaceutical industry. A new, fully automated multipurpose reactor train was installed in early 1996. The train includes ten 500 to 1500 gallon vessels used for reaction, distillation, phase separation, and crystallization; two centrifuges for isolating finished products; and two dryers.
Yokogawa Electric began offering the environmental monitoring system "OpreX Environmental Monitoring System" (hereinafter, OpreX EMS) for the pharmaceutical and medical device industries in October 2020. OpreX EMS, which was launched simultaneously domestically and overseas, is based on customers' needs, such as regulatory compliance, diversification of operational risks, and high usability. When asking the person in charge about the development history and features of the product, it was found that it is a new solution that meets the company's business vision.
Exploring the technologies needed to achieve automatic control of cell culture processes.
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The Yokogawa business vision states that the company endeavors to achieve Net-zero emissions, ensure the Well-being of all, and make a transition to a Circular Economy by 2050.
YOKOGAWA will contribute to technology evolution particularly in measurement and analytical tools to help build a world where researchers will increasingly focus on insightful interpretation of data, and advancing Life Science to benefit humanity.
Our approach is to leverage state-of-the-art technologies for real-time monitoring and predictive control that allow virtual environments where "digital twin" processes can provide distinct advantages.
Open up control. Open Process Automation (OPA) opens the door to expanded choices, leverage, and customization.
Create a scalable, sustainable architecture. Remove the restraints of proprietary systems. OPA enables you to leverage all available technologies to open up solutions. Explore the possibilities today.
As a gateway to further expand Yokogawa's messaging as a One-stop Solution Business, Yokogawa has partnered up with INCIT, to introduce the S.I.R.I. framework.
Yokogawa leverages our extensive knowledge and experience in IT, operation and control technology to build an advanced improvement cycle that is useful to all management levels, and eventually aims to achieve Pharma 4.0 together with our customers.
News
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News Brief Apr 26, 2024 Yokogawa Helps to Revolutionize the Field of Single-Cell Lipidomics
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Press Release Jan 31, 2024 Yokogawa Introduces CellVoyager High-Content Analysis System CQ3000
- For greater efficiency in drug discovery and regenerative medicine R&D, and the swift commercialization of new drugs -
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Press Release Jun 22, 2023 Yokogawa to Release OpreX Informatics Manager, Enabling Integrated Management of Experimental Data and Research Resources in the Cloud
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Press Release Feb 20, 2023 Yokogawa Enters into Partnership with Radial Software Group to Provide AI-powered Viewport Software Worldwide
- Giving customers a single view of all their technical data -
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Press Release Feb 2, 2023 Yokogawa Acquires Fluence Analytics, a Pioneer in Digitalizing the Monitoring of Polymerization Reaction Processes
- Enabling continuous real-time monitoring of polymers and biopolymers -
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