F-value Computation for the Sterilization Process for Pharmaceutical and Chemical Products

Overview

When sterilizing preserved foods by heating, bacteria must be completely annihilated without changing the heat of the product (a degradation of the taste) and the integrated fatality (F value) must be recorded and monitored. By using the computation function of the SMARTDAC+ series Paperless recorder GX/GP (relational computation, four arithmetical operations, and exponential computation), the F value can be calculated and recorded.

Setting example

Advantages

  • The F value at a specified sterilization temperature is automatically computed and recorded as production data.
  • Using external input contact, recording can be started or stopped automatically.
  • Automatic data file transfer and WEB monitoring are available.

F value

“F value” is The integrated fatality of the bacteria obtained by heat sterilization.  It is the integrated value of the fatality rate (Li) of the bacteria per unit amount of time (Δt),  and Li is a function of the sterilization temperature.

F value computation

 

Configuration Example on the SMARTDAC+

Ex. Sterilization temp. Tr=121.1degC, Z value Z=10degC,
      Measurement interval Δt=0.0167min(=1sec)

  • Constant
    K1=10, K02=10.0degC(Z value), K03=121.1degC(Sterilization temp.), K04=0.0167min(measurement Interval), K05=100degC(measurement interval)
  • Constant K2 to K5 may vary depending on the conditions.
  • Equations
    Measurement channel 0001
    MATH channel A001: K01**((0001-K03)/K02) ←Li value
    MATH channel A002:(A002+A001*K04)*(0001.GT.K05) ←F value

*When the temperature falls to 100℃, the value of A002 is reset to 0.

Temperature monitoring for HACCP

In HACCP, the temp. management is required for the whole food supply chain (ex. Food manufacturing, processing, cooking, and sales). SMARTDAC+ series can record multiple points of temp. in production lines, facilities or environment of storage …etc.
It provides strong supports for your temp. management.

Temperature monitoring for HACCP

Industries

  • Food & Beverage

    At Yokogawa, we understand that today’s food and beverage companies face unprecedented challenges in climate change, consumer demand, and increased global competitiveness. Overcoming these challenges will require innovative solutions that focus on key areas of production, asset management, and food safety and quality.

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  • Pharmaceutical

    Pharmaceutical companies must achieve increased flexibility and agility through better use and monitoring of manufacturing data to improve quality management in real time. Pharmaceutical experts work with Yokogawa to create manufacturing solutions that deliver safe and reliable medicines. Together, we use digital transformation and manufacturing advances to meet regulatory requirements, ensure quality, accelerate time to market, and thus providing a stable and reliable supply of medicine to patient.

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