|Sterilization heating temperature measurement|
In the sterilization process during pharmaceutical and food manufacturing, the "Fo" value is used as a benchmark for the sterilization time. The Fo value expresses the heating time required for disinfection, and varies according to fluctuations in heat applied to the substance being sterilized. The DX automatically calculates this Fo value from the heating temperature (the temperature measured on the DX), and is useful in managing the sterilization process by displaying and recording the value together with the heating temperature. Such careful monitoring and control allows minimization of sterilization time while maintaining the nutritional properties of the food.
- To automatically calculate the Fo value, record it along with heating conditions, and use these as QC data
- To monitor the Fo value by heating temperature, shorten the heating process, and stabilize food quality
- To install a simple, low cost, highly reliable system without using external instruments or computers
|Displays and records the heating
temperature and Fo value
The heating temperature of the substance being sterilized is measured on the DX Paperless Recorder. The Fo value is automatically calculated according to the heating temperature (temperature measured on the DX) by the DX's mathematical functions. Computed results are displayed and recorded together with heating temperature and other parameters, and saved as quality data.
Also, the DX/AS1 supports 21CFR Part 11, and allows you to save formal pharmaceutical sterilization management data for approvals.
Definition of the Fo Value
Fo= Δt ∑ 10(T-Tb)/Z
|T||Heating temperature (temperature measured on the DX)|
|Tb||121.1°C (for steam pasteurization)|
|Z||Temperature unit of logarithmic sterilization capability changes (generally, 10°C is used).|
Example of Calculation of the Fo Value on the DX
|01||Heating temperature (temperature measured on the DX)|
|31||Fo value calculation result|
|K01||1 sec or 0.125 sec (DX's measurement interval)|
|K02||121.1°C (Fixed. Equivalent to Tb in the Fo equation)|
|K03||10°C (Fixed. Equivalent to Z in the Fo equation)|
|K04||60 (sec, for conversion to units of minutes)|
DX series paperless recorders capable of automatically calculating the Fo value.
- Fo value calculated automatically by a math function (optional)
- Measured and calculated results saved electronically to local media while being displayed in real time on the large, color TFT display
- Also enables data sharing on the network (Ethernet compatible)
DX series instruments allow you to automatically calculate and process Fo values as manufacturing/quality data at a reasonable cost. Also, by constantly ascertaining the Fo value according to the heating temperature, you can optimize (shorten) the heating process, and in the case of foodstuffs, minimize excessive heating which can damage the nutritional elements in foods.
In the food manufacturing industry, in addition to the conventional challenges of achieving both "ensuring food security and safety" and "cost reduction," ｍanufacturers are also working to cope with infectious diseases and labor saving.
YOKOGAWA supports ｍanufacturers to create comfortable workplaces by working closely, coping with challenges together, and proposing ideal factories suitable for operations.
The pharmaceutical industry currently faces a major challenge in taking full advantage of the opportunities presented in large emerging markets. Now, more than ever, pharmaceutical companies need to introduce lean manufacturing techniques that will enhance profitability. As one of the world's leading industrial automation suppliers, Yokogawa is committed to delivering the best possible solutions for your best manufacturing practices.
The Daqstation DX1000/2000 series is a data acquisition system with display. Its HMI supports custom graphics for industry applications, audit trail and advanced security conforming to FDA 21CFR Part 11.
The DX1000N features a removable chassis via the front panel of the instrument. This allows easy access and maintenance of internal components of the DX1000N.
Panel mount recorders are fully integrated data acquisition and display stations with secure, built-in data storage and network connectivity. Panel-mount solutions are NEMA compliant and integrate the data acquisition equipment into a control panel.
Contact a Yokogawa Expert to learn how we can help you solve your challenges.