Managing Sterilization through Calculation of the Fo Value

Overview

Sterilization heating temperature measurement
Sterilization heating temperature measurement

In the sterilization process during pharmaceutical and food manufacturing, the "Fo" value is used as a benchmark for the sterilization time. The Fo value expresses the heating time required for disinfection, and varies according to fluctuations in heat applied to the substance being sterilized. The DX automatically calculates this Fo value from the heating temperature (the temperature measured on the DX), and is useful in managing the sterilization process by displaying and recording the value together with the heating temperature. Such careful monitoring and control allows minimization of sterilization time while maintaining the nutritional properties of the food.

Customer Needs

  • To automatically calculate the Fo value, record it along with heating conditions, and use these as QC data
  • To monitor the Fo value by heating temperature, shorten the heating process, and stabilize food quality
  • To install a simple, low cost, highly reliable system without using external instruments or computers

Process Outline

Displays and records the heating temperature and Fo value
Displays and records the heating
temperature and Fo value

The heating temperature of the substance being sterilized is measured on the DX Paperless Recorder. The Fo value is automatically calculated according to the heating temperature (temperature measured on the DX) by the DX's mathematical functions. Computed results are displayed and recorded together with heating temperature and other parameters, and saved as quality data.

Also, the DX/AS1 supports 21CFR Part 11, and allows you to save formal pharmaceutical sterilization management data for approvals.

Definition of the Fo Value
Fo= Δt ∑ 10(T-Tb)/Z

 

 

Δt Measurement interval
T Heating temperature (temperature measured on the DX)
Tb 121.1°C (for steam pasteurization)
Z Temperature unit of logarithmic sterilization capability changes (generally, 10°C is used).

Example of Calculation of the Fo Value on the DX
31= (K01*(K03**((01-K02)/K03)))/K04+31

01 Heating temperature (temperature measured on the DX)
31 Fo value calculation result
K01 1 sec or 0.125 sec (DX's measurement interval)
K02 121.1°C (Fixed. Equivalent to Tb in the Fo equation)
K03 10°C (Fixed. Equivalent to Z in the Fo equation)
K04 60 (sec, for conversion to units of minutes)

Yokogawa's Solution

DX/DXP series paperless recorders
DX

DX series paperless recorders capable of automatically calculating the Fo value.

  • Fo value calculated automatically by a math function (optional)
  • Measured and calculated results saved electronically to local media while being displayed in real time on the large, color TFT display
  • Also enables data sharing on the network (Ethernet compatible)

 

Conclusion

DX series instruments allow you to automatically calculate and process Fo values as manufacturing/quality data at a reasonable cost. Also, by constantly ascertaining the Fo value according to the heating temperature, you can optimize (shorten) the heating process, and in the case of foodstuffs, minimize excessive heating which can damage the nutritional elements in foods.

업종

  • 식음료

    Yokogawa는 오늘날의 식음료 기업들이 기후 변화, 소비자 수요 및 글로벌 경쟁력 향상이라는 전례 없는 도전에 직면해 있다는 것을 알고 있습니다. 이러한 도전을 극복하기 위해서는 생산, 자산 관리, 식품 안전 및 품질이라는 핵심 분야에 초점을 맞춘 혁신적인 솔루션이 필요합니다.

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  • 의약품

    제약 산업은 현재 대형 신흥 시장에서 발생되는 기회를 최대한 활용하는 것이 중요한 과제에 직면해 있습니다. 이에 그 어느 때보다 제약 회사들은 수익성을 향상시킬 린 제조 기술을 도입해야 합니다. 세계 최고의 산업 자동화 공급업체 중 하나인 Yokogawa는 귀사의 모범 제조 수행에 맞는 최고의 솔루션을 제공하기 위해 최선을 다하고 있습니다.

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