Tokyo, Japan - September 30, 2015
Yokogawa Electric Corporation announces the October 1 release of CellActivision, an application program for the analysis and evaluation of images of label-free cells taken using cell imaging systems or conventional microscopes. This software is also useful for controlling cell quality in regenerative medicine and iPS cell-related research.
CellActivision - Cell Image Analysis Tool
In basic research, live cells are usually observed by labeling them with a fluorescent marker and then irradiating them with a laser. However, this has a phototoxic effect and causes the cells to deteriorate. For preclinical and clinical research, or when cells are to be transplanted into the human body, the cells must be free of such effects and thus must not be labeled. However, it is very difficult to do a detailed visual analysis of label-free live cells under a conventional microscope.
Also driving the need for technologies that facilitate label-free live cell observation and analysis is the now widespread practice of using iPS cells in drug discovery research and the emerging use of tissue engineering to produce tissues and organs for transplant into the human body.
To satisfy such needs, Yokogawa is releasing this software to the market. Capable of analyzing the status of label-free live cells using images from a cell imaging system or conventional microscope, this software is based on a label-free image analysis technology that Yokogawa obtained from the Finnish company Chip-Man Technologies Oy*1 in June of this year. With this new software product, Yokogawa aims to expand its business in the rapidly growing fields of regenerative medicine and iPS cell-related research.
In most cases it is not possible to observe the activity of groups of cells and identify individual cells by type without labeling them with a fluorescent marker. In addition, no suitable conventional means is available for analyzing the status of label-free cells based on the morphological information present in their images.
Using advanced cell recognition algorithms, CellActivision is able to identify and conduct a detailed analysis of the activity of label-free live cells based on the morphological information present in images that have been captured using a cell imaging system or conventional microscope. Computer analysis of label-free live cells offers the following advantages:
Pharmaceutical companies, research institutes engaged in drug discovery and regenerative medicine, and tissue-engineered material production lines
Evaluation of drug efficacy in drug discovery research, and quality evaluation for tissue-engineered materials
*1 Founded in Finland in 2002, this limited liability company had a variety of technologies and products such as a microscope of its own design that was used in the medical and drug discovery fields. This company has been liquidated.
*2 A chemical process that causes a cessation of all biochemical reactions in a cell, thus allowing a fluorescent substance to permeate its membrane and stain a targeted protein.
Yokogawa's global network of 88 companies spans 56 countries. Founded in 1915, the US$3.5 billion company engages in cutting-edge research and innovation. Yokogawa is active in the industrial automation and control (IA), test and measurement, and aviation and other businesses segments. The IA segment plays a vital role in a wide range of industries including oil, chemicals, natural gas, power, iron and steel, pulp and paper, pharmaceuticals, and food. For more information about Yokogawa, please visit www.yokogawa.com.
Yokogawa’s high content analysis systems and dual spinning disk confocal technologies provide high-speed and high-resolution live cell imaging, enabling leading-edge research around the world.