High Content Analysis

High-content screening 시스템으로 알려진 Yokogawa의 High Content Analysis 시스템은 기초 과학에서 신약 개발 심사까지 다양한 응용 연구 분야를 다루고 있습니다. 당사의 고급 분석 소프트웨어와 함께 HCA 시스템은 향상된 세포 분석을 위한 고품질 3D 이미징을 제공합니다.

  • CellVoyager CV8000은 가장 진보된 HCS(high-content screening) 시스템입니다. 향상된 내장 인큐베이터를 사용하면 확장된 라이브 셀 반응을 분석할 수 있습니다. 이 시스템은 뛰어난 확장성과 4대의 카메라, 5대의 레이저 그리고 선택 옵션인 내장 피펫터(pipettor)를 통해 점점 더 복잡한 분석 개발 및 HCS를 수행할 수 있습니다.

  • CQ1은 공간을 절약하는 벤치탑 설계에서 최고 품질의 공초점 이미지와 확장된 라이브 셀 이미지 기능을 제공합니다.

자세한 내용은 아래 SNS 계정에서 확인하십시오.

 

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Confocal imagers with powerful analysis software

Our high content analysis systems are the best solutions for a range of research applications from basic science to drug discovery screening.

High Content Analysis

HCA is an automated research method that uses image analysis to closely examine target cells in chronological order based on single or multiple parameters. Its wide potential for investigating complex life events and phenotypes makes HCA a most promising tool for next generation drug discovery and pharmaceutical research.

Yokogawa's HCA system combines key benefits from conventional research analysis methods while addressing certain drawbacks. 

 

Traditional Methods High Content Analysis
High-Throughput Screening (HTS) Flow Cytometry Microscopy

Strength:

  • High-speed handling of a large number of samples

Weakness:

  • Calculates only averages for wells

Strength:

  • Acquires numeric data on individual cells

Weakness:

  • Adherent cells must be removed

Strength:

  • Detailed observation of cellular events

Weakness:

  • Slow

Strengths:

  • Rapidly analyzers a large number of samples
  • Detailed observation of cellular events
  • Temporal analysis of live cells
  • Acquires numeric data on invidividual cells
  • Automated high-speed imaging and analysis
  • Adherent cells can be observed as is
Application Note
Application Note
Overview:

Cell clusters are directly measured with high-throughput 3D imaging
Confocal Quantitative Image Cytometer

Application Note
Overview:

List of Selected Publications : CQ1

Application Note
Overview:

List of Selected Publications : CV8000, CV7000, CV6000

Application Note
Overview:

The CQ1 confocal image acquisition mechanism with the distinctive CSU® unit has a function to sequentially acquire fine cell images along the Z-axis and capture information from the entire thickness of
cells which include heterogenic populations of various cell cycle stages. In addition, saved digital images can be useful for precise observation and analysis of spatial distribution of intracellular molecules.
The CQ1 capability to seamlessly analyze images and obtain data for things such as cell population statistics to individual cell morphology will provide benefits for both basic research and drug discovery
targetingM-cell cycle phase.

Overview:

In this tutorial, we will learn how to perform cell tracking with CellPathfinder through the analysis of test images.

Overview:

In this tutorial, using images of zebrafish whose blood vessels are labeled with EGFP, tiling of the images and recognition of blood vessels within an arbitrary region will be explained.

Overview:

In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.

Overview:

In this tutorial, we will learn how to perform time-lapse analysis of objects with little movement using CellPathfinder, through calcium imaging of iPS cell-derived cardiomyocytes.

Overview:

In this tutorial, we will observe the change in number and length of neurites due to nerve growth factor (NGF) stimulation in PC12 cells.

Overview:

In this tutorial, image analysis of collapsing stress fibers will be performed, and concentration-dependence curves will be drawn for quantitative evaluation.

Overview:

In this tutorial, we will identify the cell cycles G1-phase, G2/M-phase, etc. using the intranuclear DNA content.

Overview:

In this tutorial, intranuclear and intracytoplasmic NFκB will be measured and their ratios calculated, and a dose-response curve will be created.

Overview:

In this tutorial, spheroid diameter and cell (nuclei) count within the spheroid will be analyzed.

Overview:

In this tutorial, a method for analyzing ramified structure, using CellPathfinder, for the analysis of the vascular endothelial cell angiogenesis function will be explained.

Yokogawa Technical Report
1.2 MB
Yokogawa Technical Report
The World as Seen from Cells
(rd-te-r06002-001)
2.2 MB
Yokogawa Technical Report
6.1 MB

Product Overviews

    Product Overview
    Overview:

    The CV8000 features a cell incubator with an improved airtight design that facilitates the observation of cell behavior over long periods of time. In addition, the CV8000 comes with CellPathfinder, a new program that can analyze images of unlabeled cells and 3D images of samples. With these features, the CV8000 improves the efficiency of drug discovery research and biomedical research on leading-edge subjects such as iPS and ES cells.

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